We demonstrated that miR-150 was functionally involved in suppressing EOC cell growth, migration and invasion, which was supported by both cell culture studies and clinical data. In cell culture experiments, overexpression of miR-150 led to the decrease of EOC cell proliferation and cell motility. In clinical samples, miR-150 was dramatically down-regulated in EOC tissues with high clinical stage and high pathological grade compared with EOC tissues with low clinical stage and low pathological grade, and low miR150 expression in tumors was associated with poor survival of patients with EOC. More importantly, our identified miR-150 target was ZEB1, a member of the zinc finger family of proteins. ZEB1 is one of the transcriptional inducer in the procedure of epithelialmesenchymal transition in cancer of epithelial origin, such as breast cancer, lung cancer, esophageal squamous cell carcinoma, gastric carcinoma, pancreatic cancer, cervical cancer, endometrial cancer and prostate cancer. Adequate evidence supports the role of the Gas6/Axl system in Peucedanol driving cell growth and survival in normal and cancer cells. Axl was originally cloned as a transforming gene in human chronic myeloid leukemia and myeloproliferative disease, and shown to transform NIH3T3 cells and render them tumorigenic in vivo. Since then, Axl overexpression and signaling has been implicated in several human malignancies, such as colon, breast, glioma, thyroid, gastric, melanoma, lung cancer, and in renal cell carcinoma. A more detailed role of Axl biology has been proven in glioma, where loss of Axl signaling diminished glioma tumor growth, and in breast cancer, where Axl drive cell migration, tube formation, neovascularization, and tumor growth. Recently, we have seen that Axl and Gas6 expression correlates to survival in a large cohort of RCC patients. Presapogenin-CP4 Interestingly, we found low Axl mRNA to independently correlate with substantially longer patient survival. Furthermore, patients with low Axl and high Gas6 mRNA levels as a combination had further increased survival.