In the past decade, studies on the relevance between drug components and effects have provided valuable information to improve TCM development, including quality control, classification, CHF prescription analysis and optimization, the identification of new medicinal plant sources, and drug design. The concept of blood stasis is described in TCM theory as a slowing or pooling of the blood due to disruption of the heart’s Qi. It is often understood in biomedical terms as hematological disorders, such as hemorrhage, congestion, thrombosis, and local ischemia. In 1998, Mchedlishvili et al reported that decreased blood flow velocity disturbs normal blood flow, which indicates hemorheological abnormalities. It was explained by pathology as a state resulting from a sluggish or impeded blood flow in the body, or abnormal blood outside the vessels that remains in the body and fails to disperse. Once blood stasis develops, the circulation will be further affected, resulting in new pathological changes. The core bioactive components of CXC that improve blood circulation impairment remain unknown. The present study was designed to assess the relationship between CXC components and circulatory effects and the specific research process was shown in Fig. 1. This study indicated that protocatechualdehyde might influence intrinsic clotting activity and could be of therapeutic interest with respect to promoting blood circulation. F4 represents RBC deformability and plasma proteins in the vascular system, which is closely related to blood microcirculatory disturbance. In this study, ginsenoside Rd had a significantly higher influence on F4 than the other components. More than 20 basic research papers on ginsenoside Rd have been recently published in many journals. In these studies, ginsenoside Rd was reported to have many different effects as a bioactive component: it could attenuate early oxidative damage and sequential inflammatory responses after transient focal ischemia in rats, relieve redox imbalance and improve ICG-001 847591-62-2 stroke outcome after focal cerebral ischemia in aged mice, and prevent the development of atherosclerosis by blocking Ca2+ influx through receptor- and store-operated Ca2+ channels in vascular smooth muscle cells. The present study provides evidence for ginsenoside Rd’s possible regulation of RBC deformability and plasma proteins, yet elucidation of the underlying mechanism requires further research. F5 represents extrinsic clotting activity in the vascular system. We found that calycosin-7-O-b-D-glucoside was most closely related to F5. It has been reported that calycosin-7-O-b-Dglucoside can increase endogenous antioxidant levels and improve cell membrane fluidity in the brains of rats subjected to experimental stroke. However, there is still no direct evidence showing calycosin-7-O-b-D-glucoside’s activity on the extrinsic clotting pathway. The present study indicates a new potential pharmacological activity of calycosin-7-O-b-D-glucoside. We determined that panaxytriol, ginsenoside Rb1, angoroside C, protocatechualdehyde, ginsenoside Rd, and calycosin-7-O-bD-glucoside were the core bioactive components of CXC and that they acted on different aspects of the vascular system.