This suggests that younger participants are less affected by environmental factors on obesity, thus highlighting the role of genetic factors. With increasing age, the cumulative effects of environmental factors may gradually override the role of genetic factors on the development of obesity. Additionally, we found that rs7206790 was significantly associated with the risks of obesity and several obesity-related metabolic traits, which was similar to the study by Seongwon Cha. Although the results were not statistically significant in other studies.We confirmed that FTO rs9939609 was strongly associated with obesity-related metabolic Dioscin traits such as WC, fasting glucose, LDL-C and HDL-C after adjusting for age, gender and location. We also found that SNPs rs7206790 and rs11644943 were associated with several obesityrelated metabolic traits such as BMI and HC. These findings suggest that the risk alleles of FTO SNPs contribute to the higher BMI and HC and to the occurrence of obesity in the school-age Chinese Han population. Previous studies have observed similar results, but the mechanisms by which FTO SNPs influence obesity and obesity-related metabolic traits remains unclear. Further functional studies are required. Obesity, a human common complex disease, is resulted from interaction of gene-environment. Studies have found individuals have diverse food selection and energy intakes because of the combined effects of genetic features and lifestyle behaviors. The associations between FTO SNPs and obesity may be explained by their effects on dietary behaviors. Increasing energy intake is a major determinant of the current obesity epidemic. A preference for high-energy foods induced by FTO SNP variations, may partially explain the predisposition to obesity. Zhifu Han, et al. reported the crystal structure of the FTO protein reveals basis for its substrate specificity, which was in complex with the mononucleotide 3-meT. The data Vincamine provided structural evidence to support the notion that FTO can act as a DNA/RNA demethylase for its functions. FTO may affect fat metabolism by influence the stability of the modified ribosome, since the main characteristics of mononucleotide 3-meT was to combine with single nucleic acid in the body.