Moreover, the database analyzed the relationships between drugs and the expression of many subtype specific genes. Therefore, EGFR targeting agent could be selected for the proneural subtype that has fewer EGFR mutation than the classical subtype. Recently, discrepancies between preclinical and clinical results of gene-based target drugs demand a reliable translational platform that can precisely recapitulate the biology of human cancers. We have established a library of orthotopic GBM xenograft Taurocholic Acid sodium hydrate models using surgical samples of GBM patients. The patient-specific orthotopic GBM xenograft library represent the preclinically and clinically valuable ����patient tumor��s phenocopy���� that represents molecular and functional heterogeneity of GBMs. According to the previous study, proneural, classical and mesenchymal subtypes exist in xenograft. Moreover, in this study, we showed that the subtypes of orthotopic xenograft tumor are well-matched with those of parental GBMs, which would potentiate the translational value of orthotopic xenograft ����AVATAR���� models for personalized medicine. In summary, we showed the possibility of personalized treatment based on gene expressional characteristics of GBMs for the first time. However, the subtype specific drugs were not perfectly specific for each subtype. Therefore, we need more sophisticated classifying techniques of GBM patients and more improved the subtype specific drug prediction methods. Based on those techniques, personalized treatment would make better clinical outcomes of GBM patients. Plakin crosslinking proteins such as dystonin and plectin have been implicated in regulating the cytoskeletal organization and function of muscle. While a number of recent studies have further defined the role of plectin in muscle tissue, much less progress has been made in elucidating the functions of dystonin in contractile cells. Several different dystonin isoforms are Pramiracetam produced through alternative splicing of the dystonin gene. Dystonin isoforms are expressed in a tissue-specific manner and include an epithelial isoform, neuronal isoforms, as well as muscle isoforms.