After the meal, the volunteers rested and consumed no food for 5 hours, but were allowed to drink water. Blood samples for Curvularin biochemical SR-58611A testing were collected before the meal and every hour during the next 4 hours, following recommendations for an oral fat tolerance test proposed by Mihas et al. in a recent meta-analysis. To determine the influence of metabolic syndrome in the postprandial metabolism, we used a general linear model of repeated measures of each postprandial parameter, with presence or not of metabolic syndrome as a between-subjects variable, blood drawing time as a within-subject variable and gender and age as covariates. Bonferroni��s correction was used for multiple comparisons. Pearson��s correlation or Spearman rank order correlation analyses were performed to examine the correlations between the levels of metabolic syndrome traits, treatment and AUC of postprandial parameters. The values of fasting triglycerides, fasting glucose, fasting HDL-c, waist circumference and both systolic and diastolic blood pressure were tested in a stepwise multiple linear regression to predict the AUC of triglycerides and determine their individual effect on it. In the present study we investigated the effect of a fatty meal on postprandial lipid metabolism in patients with coronary artery disease. We showed that MetS and the number of its components influence the degree of postprandial lipemic response. Specifically, postprandial AUC of TG showed a progressively unfavorable increase from one component to five in our population. However, this effect was attenuated when the population was divided into two groups according to the presence or absence of basal hypertriglyceridemia. Thus, only those patients without high fasting TG remained a statistically significant influence. Recently, it has been established that the presence of higher number of components of MetS is associated with an increase in subclinical atherosclerosis, and incidence and mortality of CHD. Teramura et al. reported that intima-medial thickness was significantly higher in subjects with MetS and increased with the number of coexisting components of MetS, compared with those without MetS.