Analog-to-digital detection systems are not limited to MALDI-TOF instruments, but are also incorporated into LC-TOF and LC-Q-TOF instruments as well. We expect that the same averaging approach used to enhance the mass accuracy and consistency in the AB Sciex 4800 MALDI-TOF/TOF mass spectrometer can be applied to mass spectrometers of LC-TOF and LC-Q-TOF design. These studies did not 5-Fluoroorotic acid utilize peak intensity as a parameter for averaging. Peak intensity can provide valuable data for quantitation and more consistent and reproducible quantitation would be highly advantageous. Additionally, peak intensity averaging could be readily incorporated into automated software platforms. Careful analysis of the raw peptide intensity data demonstrate that the variability in intensity measurements are much more pronounced than variability in mass measurements in the MALDI-TOF instrument. This does not imply that averaging would not improve the consistency of intensity measurements and quantitation capabilities of this instrument, but that the larger standard deviations observed would be potentially problematic for comparing multiple data sets. We note that the peak intensities observed in the LC-Q-TOF instrument were far more consistent and reproducible. However, given the high 4-Chlorophenylguanidine hydrochloride performance of current LC-TOF type instruments such as the Bruker MicroTOF-Q instrument used in these studies, the gain in data quality by averaging would be expected to be much smaller than observed for MALDI-TOF instruments. Resveratrol has attracted attention in the past years as it is assumed that consumption of red wine and thus the uptake of resveratrol are correlated with a low incidence of heart diseases despite of a saturated fat rich diet. Beside the protection from cardiovascular diseases and antioxidant properties resveratrol was described to possess antiinflammatory and antiproliferative effects. These diverse modes of action are mainly driven by modulations of important intracellular proteins like NFkB, p53, survivin, Bcl2 and the sirtuin SIRT1. Due to its multiple molecular interactions, resveratrol was analyzed for the treatment of cancer and identified to inhibit initiation and/or progression of several tumor entities like leukaemia, breast cancer, colon cancer, pancreatic cancer, gastric cancer, prostate cancer, lung cancer, melanoma and tumors of the liver. In the last years, epigenetic modulation, especially modification of DNA-associated histone proteins received attention as new targets for cancer treatment. Regarding the modifications of histone proteins, changes of the acetylation status are most pronounced. Two antagonistic enzyme families govern histone acetylation: histone acetyltransferases are involved in the acetylation of histone proteins, whereas histone deacetylases remove these acetyl groups from histone proteins.