It was found that ferulic acid was the major phenolic acid for all date varieties in Oman. In brain, the cerebrum or the cortex is the largest portion of the brain and performs most of the brain’s function. The cerebrum is divided into right and left hemispheres that are made of nerve cells which are connected by axons carrying the signals between the peripheral organs and the nerve cells. The hippocampus, an elaboration of the edge of the cerebral cortex and located in the cerebral hemisphere, is responsible for learning and memory, specifically converting temporary memories into permanent memories. These represent some regions of the brain that are susceptible to damage in neurodegenerative diseases.After measuring the levels of plasma cytokine levels, we next determined the levels of A��1�C40 and A��1�C42, since the accumulation of A�� peptides activate neuro-inflammation in AD. Brain samples were collected from the untreated control or animals supplemented with pomegranates, figs or dates. After determining the levels of pro-inflammatory cytokines in the blood plasma, we measured the levels of cytokines in the brain regions, particularly in the cortex and hippocampus. Since some of the cytokines, for instance IL-6, may act as both pro- and anti-inflammatory agents, we measured the cellular levels of these cytokines including TNF-�� and IL-1��. The basal levels of IL-1�� in the hippocampal region were 1.40 �� 0.06 pg/mg NVP-BKM120 msds protein the amounts in cortex were 0.60 �� 0.05 pg/mg protein, indicating about 2.33-fold greater amount in the hippocampus than that in the cortical region. However, in control APPsw mice, the levels of IL-1�� increased significantly, reaching 1.85 and 3.16 times greater than the basal protein levels in the cortex and hippocampus, respectively. When the animals were fed with pomegranate supplemented diet, the levels of IL-1�� decreased 1.21 and 1.50 times in cortex and hippocampus, respectively, suggesting that pomegranates and other fruit supplementation could indeed reduce the levels of IL-1�� and decrease neuroinflammatory activities. A similar trend was observed in the experimental animals that were fed with figs, or dates. However, the protective effects of pomegranates were more prominent, and followed by diets supplemented with figs or dates. The cellular levels of TNF-�� and IL-6 in both cortex and hippocampus in Tg mice were higher as compared to those in wild control mice. However, the elevated TNF-�� and IL-6 levels in both cortex and hippocampus in Tg mice were suppressed after the Tg mice were fed with diets supplemented with pomegranates, figs, or dates. Many experimental animal models for AD are available to study the pathogenesis mechanisms and translational research. For instance, the proposed model for neurodegeneration in AD brains is based on free radical mediated oxidative stress associated with A��1�C40 and A��1�C42 accumulation. The role of Met-35 as a mediator of the toxicity of A�� is more likely to involve an oxidative event at the sulfur atom, leading to lipid perNVP-BEZ235 oxidation and protein oxidation in neuronal membranes. However, the event that initiates the oxidation of Met-35 is not yet clear. The increased levels of A�� in AD have been shown.