With increased expression of BDNF show better performance in cognitive tasks. Modulation of oscillatory activity by BDNF could be one of the mechanisms responsible for those behavioral changes. Surgical procedures such as liver resection and liver transplantation are the first-line treatments for HCC patients. However, the high incidence of tumor recurrence and metastasis after liver surgery remains a major problem. Therefore, it is a pressing need to develop novel therapies to eliminate tumor recurrence and metastasis after liver surgery. Surgical stress injury such as hepatic ischemia reperfusion injury is an inevitable consequence during liver surgery. Hepatic I/R injury promote liver tumor growth and metastases through activation of cell adhesion, invasion, and angiogenesis pathways. Furthermore, accumulating evidence indicated that surgical stress injury can rapidly increase the number of circulating EPC. These events are also associated with elevated levels of vascular endothelial growth factor, stem cell factor, and granulocyte colony-stimulating factor that stimulate the Ganoderic-acid-D release of EPCs from the bone marrow. EPCs, a subtype of progenitor cells in postnatal bone marrow, have the capacity to migrate to the peripheral circulation and differentiate into mature endothelial cells. Several researches have showed that circulating level of EPCs is higher in patients with advanced HCC, which may act as a potential prognostic marker in HCC patients. Furthermore, EPCs play important roles in tumor vasculogenesis and tumor growth at early phase by providing structural support to nascent vessels and the release of pro-angiogenic cytokines. EPCs have major roles in the tumor progression from micrometastases to macrometastases. FTY720, is HJC0350 synthetically derived from myriocin, a metabolite isolated from ascomycete, Isaria sinclarii. FTY720 has been demonstrated to attenuate hepatic I/R injury by ameliorating acute phase inflammatory response and up-regulating several protective genes including heat shock proteins and antiapoptotic genes. Recently several groups have shown that FTY720 has a strong antitumor effect on liver cancer, breast cancer, bladder cancer, and prostate cancer. Therefore, our hypothesis was that FTY720 may suppress liver tumor metastasis after liver surgery through attenuating hepatic I/R injury and subsequently reducing circulating EPCs. In this study, we aimed to investigate whether FTY720 suppresses liver tumor metastasis after liver tumor resection and partial hepatic I/R injury by attenuating hepatic I/R injury and reducing circulating EPCs level in an orthotopic rat liver tumor model. The significance of this study will hopefully open a novel therapy to reduce liver tumor metastasis after liver surgery for HCC patients.