The stop-signal task measures both the efficiency of response execution and the efficiency in inhibitory control. Following our reasoning, we expected that recreational users compared to cocaine-free controls would show a selective deficit in the ability to Coptisine-chloride inhibit but not in the execution of response for the observations of these pattern of results in chronic users]. These observations led us to expect first, a positive correlation between lifetime cocaine exposure and impairment in inhibitory control and, second, that recreational users did show impaired inhibitory control but to a smaller extent than reported for chronic users. This study tested, for the first time, whether the recreational use of cocaine is associated with a detectable selective impairment in the ability to inhibit responses. Our findings suggests an affirmative answer: recreational users showed normal response speed but impaired inhibitory control, and the size of this deficit seems to correspond to the amount of cocaine consume. Hence, the greater the dose and the frequency of cocaine use, the greater the magnitude of the loss of inhibitory control seems to be. In view of evidence Gluconate Calcium suggesting that cocaine is accompanied by a selective effect on DAD22, our findings are consistent with the hypothesis that dopamine modulates response inhibition. In contrast to numerous previous studies of chronic cocaine users, the design of our study allows us to reject a number of alternative accounts of our observations. Participants were screened for several psychiatric disorders and matched for age, IQ, sex, and alcohol consumption, which rules out accounts in terms of pre-existing psychiatric disorders that are known to affect response inhibition. Particularly important was the matching of the age range: While inhibitory control seems not to be related to general intelligence, there is evidence that cognitive inhibitory process declines throughout the life span. Given that MDMA is associated with impairments in working memory processes and cannabis is related to dysfunctions in cognitive flexibility and that both drugs seem not to be linked with malfunction in inhibitory control function, we doubt that our results can be attributed to the use of marijuana and MDMA.