miRNAs play diverse roles in normal cellular processes such as cell cycle

Further studies are warranted to establish the utility of SCD-1 in treatment of IA as it presents a lead for development of potent antifungal therapies. Breast cancer is one of the leading health concerns worldwide, affecting over one million women every year. In Lebanon, it is one of the most common type of cancer constituting about one third of all female cancers. Interestingly, a significant number of Lebanese breast cancer patients were noted to be of young age at the time of diagnosis as 22% of the cases were below the age of 40 years old compared to 6% in the Western populations. Moreover, Lebanese women who are diagnosed at young age and in their premenopausal state were shown to present with a more aggressive disease and poorer survival in spite of adequate therapy. The presence of signs of more aggressive features in breast cancer in young women, and the occurrence of breast cancer in young Lebanese women 10 years earlier in age than those in the West, strengthens the importance of determining the biological factors behind those differences, and perhaps revealing novel biomarkers for early screening and detection of breast cancer. Since the discovery of microRNA in C. elegans twenty years ago, this major subclass of non-coding RNA molecules act as gene modulators mostly at the posttranscriptional level by causing translation repression or degradation of mRNA. Argatroban miRNAs play diverse roles in normal cellular processes such as cell cycle, proliferation and apoptosis as well as in disease conditions including cancer, diabetes, neuro-degenerative disorder and cardiac hypertrophy. miRNA was first correlated with breast cancer by Iorio and his colleagues. Using microarray analysis, they discovered a Ginsenoside-Rh3 differential miRNA profile pattern between cancerous and normal breast tissues. miRNAs were later shown to modulate tumor suppressor and oncogenic pathways thereby contributing to the different stages of breast cancer and acting as regulators of cell cycle progression, apoptosis, angiogenesis, epithelial to mesenchymal transition, tumor microenvironment, migration, invasion and metastasis.

Leave a Reply