Previous findings have demonstrated a benefit of intraperitoneal or Cucurbitacin-E intravenous administration of UA in experimental models of several disorders that involve increased oxidative stress including multiple sclerosis, Alzheimer��s disease, stroke and spinal cord injury. However, the relative insolubility of UA and its ability to form toxic crystals reduces its clinical utility. We recently reported on the development of novel UA analogs with greatly increased solubility and potent antioxidant acitivity. In vitro and cell culture screening identified 1, 7-dimethyluric acid and 6, 8-dithiouric acid as two analogs with high antioxidant and neuroprotective activities. When administered intravenously in mice, both UA analogs lessened damage to the brain and improved functional outcome in an ischemia�Creperfusion mouse model of stroke. In the present study we provide evidence that topical administration of 6, 8-dithiouric acid accelerates wound healing in mice by a mechanism that may involve actions of the UA analog on fibroblasts, Homoori-entin keratinocytes and vascular endothelial cells. These findings show that soluble UA analogs can improve wound healing and suggest novel therapeutic uses for UA analogs in clinical settings. Impaired wound healing continues to be a major health problem that predisposes to infections, long-term morbidity and mortality, particularly in high risk patients including those with diabetes or suppressed immune function, and the elderly. In a previous study we screened a panel of soluble UA analogs to establish their antioxidant and neuroprotective properties and identified 1, 7 dimethyl-uric acid and 6, 8 dithio-uric acid as being the most effective. In the present study we found that UA2 was much more effective than UA or UA1 in promoting the proliferation and migration of dermal fibroblasts, keratinocytes and vascular endothelial cells. We then tested the therapeutic potential of UA2 in a mouse model of wound healing and found that, indeed, topical application of UA greatly accelerated wound healing and enhanced the restoration of normal dermal and epidermal tissue structure in the wound area.