Our findings shed light on the pathogenesis of virus-induced asthma exacerbations. In the setting of a viral upper respiratory tract infection, the deficiencies in innate immune pathway are likely to lead to an increased viral load, exaggerated lower airway inflammation and exacerbation of asthmatic symptoms. We have recently shown that another important consequence of decreased innate IFN production is an increase in TH2 cytokine synthesis by virus-specific memory T-cells that might intensify preexisting TH2 mediated airway inflammation during HRV infection. Whether or not low IFN production and/or pDC dysfunction also contribute to a failure of immune Deferasirox regulatory mechanisms is currently under investigation. Taken together, our findings emphasise that decreased type-I IFN production has important consequences to patients and elucidation of the mechanisms behind this should be a key focus of research in the asthma field. Mental Deficiency and Autism Spectrum Disorders are frequent pathologies appearing during childhood. They are both characterized by impairments in cognitive functions, social integration, and/or Butamben communication. Apart from this ����core���� deficit, hallmark for diagnosis of MD and ASD, patients frequently demonstrated a range of sensory abnormalities. Indeed, atypical responses to sensory stimulation have been reported in approximately 70�C 90% of individuals with MD or ASD. Sensory impairment is defined as the inability to interpret outside stimuli such as visual, auditory, verbal, sense of touch, taste, smell or feeling pain, and may manifest as both hyper and hyposensitivity to stimulation. Among hypothesis underlying the neurophysiological basis of such impairments, the mis-wiring of neuronal connections in the developing brain and synaptic destabilization had been reported. Indeed, MD or ASD have been linked to cerebral dysregulation of axon growth/guidance and dendrite spine maturation leading to synaptic defects. Currently, sensory impairments are attributed to a cerebral phenotype. Fragile X Syndrome is the most common form of MD with ASD features.