On the one hand, some reports have shown higher IgG anti-HEV rate in HIV-infected, in contrast to general, population. Moreover, Mateos-Lindemann ML et al has recently published an IgG anti-HEV rate of 10.4% in a cohort of HIV-infected patients from Spain, a rate higher than the previously reported 2.8% of the general population from that area of Spain. On the other hand, reports from England and France, have shown a similar or even lower seroprevalence of HEV infection in HIVinfected patients. The reason for a possible higher anti- HEV seroprevalence in HIV-infected patients remains unknown, though this fact could be related to blood transmission of both infections. What is more,SR144528 some cases of HEV infection transmitted by blood products have been reported worldwide, and also use of intravenous drugs has been associated to a higher IgG anti-HEV rate than in the general population. A limitation of our study is the anti-HEV IgG test used. In recent years, the assays for the determination of anti-HEV have improved, and some studies have revealed that a Chinese assay, Wantai test, which is not commercialized in Europe, could be more sensitive. However, the aim of our study was not establishment of absolute prevalence,ISAM-140 but the search for risk factors associated with HEV infection, and for this reason we test in the same manner a large cohort of immunocompromised patients, probably the most extensive to date. In conclusion, the main insight of our study is the high HEV seroprevalence observed in liver-transplant patients and the strong association between anti-HEV with liver cirrhosis. These results suggest that HEV should be considered in the differential diagnosis of otherwise unexplained hepatitis and HEV screening should be implemented prior to liver transplantation. In the United Kingdom, General Practitioners receive payments for chronic disease management of patients with coronary heart disease and for screening these patients for depression. This is because a possibly bi-directional association between depression and CHD is now accepted. CHD registers are thus held in general practice, but little is known about the characteristics of those placed on these registers.