GABAergic dysfunctions and alterations in inhibitory circuits of the brain have been implicated in several mouse models of schizophrenia and related disorders ). We suggest that by influencing GABAergic signaling through vesicle trafficking, TMPAP might be linked to specific endophenotypes seen in neurological and neuropsychiatric disorders. Residents carry out much of daily patient care, while being learners at the same time. Therefore, patient care quality benefits from adequate supervision of residents. To assess adequate supervision in residency training, attending physicians are increasingly evaluated on their clinical teaching performance. Systems and tools for robust evaluation of teaching performance are available and high and low performing attending physicians can be identified. Research suggests that attending physicians who are younger, female and spend more time on teaching and conducting research, are more favorably evaluated on their teaching performance. In addition, which is in line with well documented personality research in the field of job performance and academic performance in medicine. Yet, personality research on teaching performance of attending physicians is limited and uses qualitative methods only. Understanding the plausible link between them can shed critical light on opportunities and policies regarding the development paths and career planning of attending physicians in medical education. What are personality traits and in what way could they affect teaching of attending physicians? Personality traits can be categorized in five comprehensive domains, called the Five Factor Model: conscientiousness, extraversion, emotional stability, agreeableness and openness. Conscientiousness refers to dependability and includes traits such as being responsible, organized, orderly and thorough. Employees who are conscientious take responsibility for their work, accomplishing their work tasks more thoroughly and orderly. Ultimately, university teachers who are orderly are better evaluated and physicians who are conscientious are thought to be good teachers in medicine. Higher levels of conscientiousness of attending physicians could positively influence their teaching in residency training, as training of residents is an important responsibility. Yet, the role of conscientiousness in clinical teaching practice remains unexplored. Extraversion means being sociable, talkative, outgoing and active. Extraverted people perform better in professions involving social interaction. Unlike research on the other four personality traits, research on the working mechanism of extraversion with respect to social interaction provided a neurobiological explanation. That is, extraverts have lower cortical activity than introverts. This makes extraverts seek to attain a higher level of arousal by increasing social activity, while the higher levels of cortical activity of introverts.