In addition, Beatty et.al.revealed that the 6MWTD can predicts MACE in a broader population of patients with stable CHD, independent of traditional risk factors and markers of cardiac disease severity. Treadmill exercise testing will remain the preferred modality for evaluating patients with suspected ischemia. Amikacin hydrate However, for STEMI patients undergoing risk stratification for further intervention, the 6MWT offers potential advantages. The 6MWT can be conducted with little equipment other than a hallway marked for distance and a stopwatch. Due to the self-paced nature of the test, side effects of chest pain, dyspnea, or musculoskeletal pain are usually mild; serious adverse events have not been described. Further, the 6MWT is less expensive than treadmill exercise testing. The ability of the 6MWT, a simple office-based test of functional exercise capacity, to predict outcomes in patients with stable CHD is especially relevant because the 6MWT addresses physical activity, a modifiable risk factor for secondary prevention of CHD. While we 
have demonstrated in the present work that the 6MWTD can predict cardiovascular events in STEMI patients, however, its use for improving prognosis merits further study. The use of Treadmill exercise stress test as a control group was not valid in this study however, we recommend adding it in future studies. We cannot exclude the possibility of selection bias in the main cohort of participants, since many CCU admitted patients were not enrolled in the study for logistical reasons. Patients were excluded from the study if they were unable to walk. Thus, the results may not extend to patients with significant angina or other limitations in walking. The transcripts of lncRNAs contain more than 200 nucleotides and have little or no potential translation. Although once thought to have no function, the expression of these novel RNAs have been shown to be cell type-specific, localized to sub-cellular compartments, and associated with diverse human diseases including a number of cancers. Correlations between lncRNA expression and cancer has attracted worldwide research attention, as well the reported functions of lncRNAs in gene expression regulation, splicing, epigenetic control, chromatin structure, and nuclear transport. Such correlations may be positive or negative. For example, the well-known lncRNA Hox antisense intergenic RNAis a powerful predictor of metastasis and poor prognosis, and is overexpressed in breast cancer, hepatocellular carcinomaand colorectal cancer, to name a few. Conversely, the lncRNA maternally expressed gene 3is downregulated in HCC, and enforced expression of MEG3 in HCC cells significantly decreased both anchorage-dependent and anchorage-independent cell growth, and induced apoptosis. Renal cell carcinomais one of the most Ascomycin common malignant cancers in China. It was estimated that 37.7 men and 16.6 women per 100,000 Chinese were diagnosed with RCC in 2005. The disease is the third most common genitourinary cancer, and for the year 2008 in the United States 54,390 casesand 13,010 deaths were expected. Although in most patients RCC is primary, up to 40% will eventually develop metastases. Patients with metastatic RCC have a median survival of only 6�C12 months and only 9% survive 5 years, largely because of strong resistance to chemotherapy and radiotherapy and the lack of effective therapeutics.