Defects in the C1-tetrahydrofolate metabolic pathway may decrease the levels of vitamin B12. It is possible that the inconsistent findings associating rs6922269 with various heart disease phenotypes in this and other studies may be due in part to MTHFD1L gene-environment interactions, particularly dietary variation in folate content leading to variation in folate metabolite levels and therefore risks of disease progression. Folate status and drug treatment regimen have undergone substantial changes in New Zealand during the decade between the median dates of recruitment for each cohort. However it must be acknowledge that this interpretation of the data is circumstantial and as such should be viewed as hypothesis generating. Further studies of the utility of rs6922269 as a diagnostic and prognostic marker in CHD patients are needed, with particular emphasis on participants’ dietary intake and nutritional status, especially folate pathway metabolites. While a recent large meta-analysis of GWAS markers for dyslipidaemia, Coptisine-chloride diabetes and CHD found rs6922269 was associated with CHD risk, investigation of the association of rs6922269 with survival 
in patients with established CAD has been limited. A recent GWAS of mortality after ACS identified rs6922269 as the only SNP of 95 investigated to achieve Bonferroni-corrected significant association with mortality in the test cohort. This finding was replicated in the African-American subgroup of a second cohort, but not in two additional independent cohorts, resonant with our own results. Gastric cancer is one of the most common malignant diseases worldwide. The prognosis of gastric cancer is poor and patients are generally diagnosed at a rather advanced stage in most countries. Thus, the overall 5-year survival rate is about 40%, and that of the patients with distant metastasis is less than 5%. Approximately 700,000 gastric cancer patients die annually, making it the second most common cause of cancerrelated death worldwide. Data showed that the crude mortality rate of gastric cancer was 25.2 per 100,000. But there exists remarkable geographical variation in incidence of gastric cancer for eastern countries such as China and Japan have highest rates of gastric cancer than western countries. In China, gastric cancer is the second most frequently diagnosed cancer and the third leading cause of cancer death, with an estimated 464 439 new cases and 352 315 cancer deaths in 2008. The overall estimated age-adjusted incidence rate in 2008 was 29.9 per 100,000 people in China. So, gastric cancer remains a significant problem worldwide despite a declining incidence in not only western countries but also China. MicroRNAs are a class of highly conserved, singlestranded, small noncoding RNA molecules, which are known as endogenous regulators of post-transcriptional gene expression regulating expression through translational repression and messenger RNA cleavage. They can inhibit gene expression at the posttranscriptional level by binding to the 39 Saikosaponin-C untranslated region of target mRNAs can result in mRNA degradation or translation inhibition, depending on the degree of complementary base pairing.